NCT06099587 · RECRUITING
MIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's Disease
This pilot study is testing whether a specialized type of MRI scan — high-resolution diffusion MRI — can detect very early brain tissue changes linked to Alzheimer's disease in people who already notice memory problems but do not yet have dementia. Researchers want to know if this scan, combined with memory testing, could serve as an affordable, non-invasive early marker. Phase NA means this is a feasibility or observational study, not a drug trial.
You may qualify if
- aged between 50 and 80
- native French speaking
- right-handed
- with a level of education equal to or higher than the Certificat d'Etudes Primaires (primary school leaving certificate)
- free of any medical or psychiatric condition likely to interfere with cognition, other than a diagnosis of SCD / MCI
- affiliated with a social security scheme
- having received oral and written information abou the protocol and having signed a consent form to participate in this research
- patients with 'subjective cognitive decline-plus' (hereafter 'SCD', criteria of Jessen et al., 2014) or patients with mild neurocognitive impairment due to Alzheimer's disease (hereafter 'MCI', criteria of Albert et al., 2011)
You're excluded if
- contraindications to MRI : Abdominal circumference + upper limbs stuck to the body > 200 cm; Implantable pacemaker or defibrillator; Neurosurgical clips; Cochlear implants ; Neural or peripheral stimulator; Intra-orbital or encephalic metallic foreign bodies; Endoprostheses fitted less than 4 weeks ago and osteosynthesis devices fitted less than 6 weeks ago; Claustrophobia.
- sensory deficit interfering with experimental tests
- pregnant or breast-feeding women
- adults under legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty
- 7-items modified Hachinski ischemic score >2 (Hachinski et al., 2012)
- Dementia (McKhann et al., 2011)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-06-17