NCT05929924 · COMPLETED
Does EVOO Induce Gene and Metabolic Changes in Healthy Subjects
Sponsor: Augusta University
This trial is testing whether adding extra virgin olive oil (EVOO) to your daily diet changes gene expression, lipid profiles, and metabolic markers in healthy adults who have a family history of Alzheimer's. Participants get about two tablespoons of EVOO a day for six months, and researchers will take blood samples before and after to look for biological changes. This is a Phase NA study — it is exploratory research, not a test of a proven treatment.
You may qualify if
- Cognitively normal and healthy individuals
- Have a family history of Alzheimer's disease.
You're excluded if
- Smokers
- Neuropsychiatric illness including depression, anxiety, seizures, attention deficit disorders, and cognitive deficit disorders.
- Pregnant or become pregnant during the study.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-11-03