NCT05740683 · RECRUITING
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
This study looks at people aged 55 to 75 who have lost their sense of smell for no known reason. It uses a lab test called RT-QuIC, which looks for misfolded alpha-synuclein protein, a marker linked to Parkinson's and related conditions. Researchers also track early neurological symptoms. It is a diagnostic study, not a treatment, and no phase is listed.
Eligibility criteria
Inclusion criteria with patients iOD: * Age 55 -75 years of age * Slowly progressing and non-fluctuating iOD * Able to give informed consent and to cooperate as evaluated by the PI Exclusion criteria with patients iOD: * Diagnosed with a neurodegenerative disease or major neurological/psychiatric condition. * Anosmia/hyposmia caused by sino-nasal disease (including chronic rhinitis and allergy), after trauma, infection, congenial, olfactory dysfunction due to surgery, or toxins/drugs affecting the olfactory function. * Olfactory dysfunction with response to systemic or local corticosteroids if tried * Severe nasal cavity abnormalities or infections. * Overt signs of dementia or PD * Current alcohol or drug abuse * Terminal illness * Diagnosed with neurodegenerative disease or major neurological/psychiatric condition. Inclusion criteria controls: * Age 55 -75 years of age * Able to give informed consent * Able to cooperate as evaluated by the PI Exclusion criteria controls: * Olfactory dysfunction on clinical test * Overt signs of dementia or PD * Severe nasal cavity abnormalities or infections. * Current alcohol or drug abuse * Diagnosed with neurodegenerative disease or major neurological/psychiatric condition.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-10-02