NCT05586750 · Phase 4 · ACTIVE NOT RECRUITING
Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy
This substudy compares atorvastatin, a common cholesterol-lowering statin, with a placebo over four years. Researchers use brain MRI scans to look at markers of brain health, such as white matter changes. It is a Phase 4 trial, meaning the drug is already approved for other uses and is being studied further. It does not show the statin protects the brain.
You may qualify if
- Participants in the STAREE RCT and eligible for randomisation to study medication.
- Men and women
- Aged ≥70 years
- Living independently in the community
- Willing and able to provide informed consent and agree to participate in brain neuroimaging.
- Able to attend one of the 2 sites (in Melbourne and Brisbane) where the imaging will take place.
You're excluded if
- Contraindications to have magnetic resonance neuroimaging performed.
- History of invasive brain surgery or known structural bran abnormalities.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-05-22