NCT05579236 · ACTIVE NOT RECRUITING
Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease
This study tests a new way of analyzing brain MRI scans, called Cortical Disarray Measurement, to see if it can help diagnose Alzheimer's disease in people who already have memory and thinking problems. It also looks at how the scan results track with changes in thinking over time. No drug is given. The phase is not specified.
Eligibility criteria
PATIENT PARTICIPANTS Inclusion Criteria: * Diagnosis of mild cognitive impairment (MCI) or prodromal Alzheimer's Disease (AD) as defined by National Institute on Ageing/Alzheimer's Association (NIA/AA) diagnostic criteria for MCI/prodromal AD, NOT including MCI unlikely due to AD; OR, Diagnosis of Alzheimer's disease as defined by NIA/AA criteria for probable AD * Clinical dementia rating (CDR) scale global score of very mild or mild (0.5 or 1) impairment * Ability to undergo and tolerate MRI scans, with no contraindications to MRI * Ability to tolerate blood draws * Ability to give informed consent to participate in the study Exclusion Criteria: * Do not meet the inclusion criteria * No study companion available * Individuals with a non-progressive learning disability * Pregnant or intending to become pregnant during the study COMPANION PARTICIPANTS Inclusion Criteria: * Aged over 18 years * Sufficient knowledge on study participant's condition to complete companion assessments of the patient, in the investigator's judgement * Able and willing to attend all clinical visits for completion of companion assessments or provide the relevant assessments remotely via phone or video call Exclusion Criteria: * A condition or reason, in the investigator's judgement, that would question the validity of the acquired companion reported data * Individuals who are not fluent in English
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-07