NCT05464355 · ACTIVE NOT RECRUITING
Biomarkers Associated With Postoperative Cognitive Dysfunction
This study looks at whether brain-wave recordings (EEG) during surgery and two blood tests, neurofilament light chain and tau, can predict confusion and memory or thinking problems after surgery in people over 65. It is an observational feasibility study. It tests whether the approach is workable, not a treatment. No phase was listed.
You may qualify if
- Greater than or equal to 65 years of age
- Having elective non-cardiac surgery under general anaesthesia
- Anticipated to have at least 48 hours of inpatient admission
- Able \& willing to give informed consent
You're excluded if
- Unable to participate in neurocognitive assessments
- Presence of delirium prior to surgery
- Contraindication to use of EEG electrodes (e.g. known allergy to a component of the electrodes)
- Known history of severe traumatic brain injury
- Learning disability specifically with a known structural brain lesion
- Known history of dementia
- Participants undergoing operations on the carotid artery
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-06-22