NCT05077618 · RECRUITING
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
This is an observational case-control study, not a treatment trial. Researchers are collecting dental plaque and blood samples from people aged 70 and older, comparing the oral bacteria of those with Alzheimer's disease to those without it. The goal is to identify whether specific mouth bacteria are linked to Alzheimer's. No phase is listed because nothing is being tested as a therapy — this is early discovery science.
You may qualify if
- ge greater than or equal to 70 years old
- Patient (or trusted person) having read and understood the study information note and signed the informed consent form
- Membership in a social security scheme
- for cases : Diagnosis of possible or probable Alzheimer's disease according to the DSM-V
You're excluded if
- Presence of a neurodegenerative pathology (excluding Alzheimer's disease for cases)
- Presence of a neurocognitive disorder (excluding Alzheimer's disease for the cases)
- Patient with or having had any kind of cancer, including oral or aerodigestive tract
- Patients with or having had autoimmune diseases (HIV, hepatitis)
- Patients with inflammatory diseases (such as rheumatoid arthritis (RA) or Gougerot-Sjogren's syndrome (GSJ))
- Patients with severe haemopathy
- Patients with severe acute or chronic cardiovascular, renal, hepatic, gastrointestinal, allergic, endocrine, pulmonary, neuropsychiatric pathologies, judged by the investigator to be incompatible with the study, as all these pathologies may interfere with the results of the oral flora sampling
- Patients who have undergone oral surgery in the two months prior to sampling
- Patients treated with oral retinoids, bisphosphonates, oral anticoagulants or anticonvulsants
- Patients who have had anti-cancer or immunosuppressive chemotherapy within the last 6 months
- Patient who has had antibiotic or anti-inflammatory treatment in the last 4 weeks
- A history of treatments (drugs and probiotics) taken in the month prior to sampling will be taken, as well as a record of toxic habits (tobacco, alcohol, other)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-03-20