NCT05060848 · ACTIVE NOT RECRUITING
Plasma Hydrogen Sulfide as a Biomarker for Alzheimer's Disease and Related Dementias
This study measures hydrogen sulfide, a molecule tied to blood vessel health, in blood samples. Researchers will compare levels in people with and without dementia. They will also look at links to thinking skills and small-vessel changes in the brain. No drug or treatment is being given. It is an observational study, so there is no phase.
You may qualify if
- All participants must be aged >55 years with English as the 1⁰ language, with stable permitted medications for \<4 weeks, geriatric depression scale score \<6, visual and auditory acuity adequate to perform tests, and history of education excluding developmental cognitive abnormalities.
You're excluded if
- Exclusion criteria are history of significant neurologic disease or mental illness, unstable medical conditions that could interfere with completion of study, substance abuse within 2 years, contraindications to MRI, abnormal findings on MRI, history of chronic kidney disease, and investigational agents within 1 month of participation.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2023-03-08