NCT04070703 · ACTIVE NOT RECRUITING
Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment
This trial is testing whether a specially designed Tai Ji Quan program can improve memory and thinking skills, as well as the ability to do two things at once, in older adults with mild cognitive impairment. It is a behavioral intervention study, not a drug trial, meaning researchers are measuring whether this structured movement practice makes a meaningful difference in brain function over 24 weeks, with a 6-month follow-up.
You may qualify if
- complaint of memory loss
- clinical dementia rating (CDR) scale score ≤0.5
- having normal general cognitive function screened, with MMSE ≥24
- capable of exercising safely, as determined by a healthcare provider
- willingness to be randomly assigned to an intervention condition and complete the 24-week intervention and 6-month follow-up
You're excluded if
- having medical conditions likely to compromise survival, such as metastatic cancer, or render a participant unable to engage in physical activity, such as severe cardiac failure
- participating in any type of Tai Ji Quan or daily and/or structured vigorous physical activity (i.e., brisk walking for exercise 30 minutes or longer at a time, or engaging in muscle-strengthening activities, e.g., weight lifting on 3 or more days per week 3 months prior to the study)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-08-26