An observational study of factors influencing age of onset of Alzheimer’s disease and disease progression

Eligibility criteria

Inclusion Criteria:
Inclusion criteria for age of onset Alzheimer’s disease patients:
1. Male and female participants
2. Aged between 45-84
3. Diagnosis of Alzheimer’s disease (50 aged 45-54, 50 aged 55-64, 50 aged 65-74, 50 aged 75-84)
Inclusion criteria for ‘other dementia’ group in age of onset study:
1. Male and female participants
2. Aged between 45-84
3. With an ‘other’ diagnosis of dementia (i.e. NOT Alzheimer’s disease) including but not limited to: Vascular Dementia (VaD), Frontotemporal dementia (FTD), Dementia with Lewy Bodies (DLB)
Inclusion criteria for MCI group in age of onset study:
1. Male and female participants
2. Aged between 45-84
3. A diagnosis of Mild Cognitive Impairment (MCI)
Inclusion criteria for apparently healthy cohort in age of onset study:
1. Men and women
2. Aged between 45-84 (50 aged 45-54, 50 aged 55-64, 50 aged 65-74, 50 aged 75-84)
Inclusion criteria for imaging sub study:
1. Men and women
2. Aged 45-84
3. Diagnosis of MCI, Alzheimer’s disease, other dementia and healthy controls (25 per group)
Exclusion Criteria:
Exclusion criteria for all age of onset participants:
Participants with a bleeding disorder, for which, blood sampling would not be advisable.
Exclusion criteria for imaging sub study:
1. Participants with a bleeding disorder, for which blood sampling would not be advisable
2. Pregnancy
3. Previous head or neck surgery
4. Suffer from epilepsy or migraine
5. Active implants (pacemaker, neurostimulator, insulin pump, ossicular prosthesis)
6. May have metal fragments in the body
7. Have jewellery/piercings that cannot be removed
8. Suffer from claustrophobia

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2020-07-13