Virtual Reality Training to Support Daily Activities for People Living With Dementia

Eligibility criteria

Inclusion Criteria:
* Clinical diagnosis of Alzheimer's disease or a dementia-related condition that shares similar or overlapping symptoms with Alzheimer's disease, confirmed by a licensed healthcare provider (e.g., neurologist, geriatrician, or primary care physician); for caregiver-reported diagnoses, supporting documentation must be obtained prior to enrollment.
* MMSE score between 20 to 25 (mild dementia)
* Capacity to consent
* Ability to engage meaningfully in at least one IADL task relevant to the intervention, ensuring capacity to interact with the functional tasks targeted within the VR system.
* Safe, quiet home environment appropriate for VR, with access to an indoor space suitable for engaging in study activities:
At least 3 × 3 feet of unobstructed floor space. Adequate lighting to clearly view the device and physical surroundings. Stable chair without wheels for VR use.
* Willingness and ability to follow the study protocol, including completion of 30-minute intervention sessions five times per week for four weeks and participation in assessment sessions at baseline (Week 0), post-intervention (Week 4), and follow-up (Week 8).
* English language proficiency sufficient to complete the intervention and assessments, including interviews, cognitive testing, and interactive VR tasks.
* Participants must have access to a smartphone, owned by the participant or their caregiver, and be willing to use it to host the VR application.
Caregivers' inclusion criteria include:
* Age 18 years or older
* Primary familial or spousal caregiver who provides daily care
Exclusion Criteria:
* Impaired reasoning/judgment that affects daily life
* Severe visual, hearing, or motor impairments that would limit the participant's ability to use VR safely or engage with the system's content.
* Significant psychiatric or neurological conditions (e.g., active psychosis, uncontrolled depression, recent seizures) that may interfere with participation or safety.
* Medical conditions that pose safety risks, including those that could be aggravated by visual immersion (e.g., uncontrolled vertigo, history of VR-induced motion sickness).
* Significant acute or chronic medical, neurological, or other illnesses that, in the judgment of the principal investigator (PI), could compromise participant safety, hinder study completion, or interfere with study objectives.
* Concurrent participation in other interventional studies, particularly those involving cognitive rehabilitation or VR, that may confound study results.
* MMSE score below 20, indicating cognitive impairments more advanced than mild dementia.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-09-21