NCT07779863 · NOT YET RECRUITING
Acupressure as Long-term Intervention to Slow the Progression of Early/Mild Alzheimer's Disease
This trial tests whether a structured acupressure routine, given three times a week for a year by trained caregivers, can slow cognitive decline in older adults with early or mild Alzheimer's disease. It compares a fuller acupressure protocol against a minimal-touch control, tracking cognitive scores and blood biomarkers. It's a non-drug study, not yet proven effective.
You may qualify if
- have at least one of the following abnormal plasma amyloid and tau levels: Aβ42/Aβ40 ratio ≤ 0.17, p-tau217 > 0.15 pg/ml, or/and p-tau181 > 3.3 pg/ml
- have mild neurocognitive disorder with the Montreal Cognitive Assessment, Hong Kong version (HK-MoCA) in classifying mild neurocognitive disorder, in which mild neurocognitive disorder is defined as those whose HK-MoCA score falls between the 16th and 2nd percentile of his/her peers adjusted for age and education
You're excluded if
- show moderate-to-severe dementia, as evidenced by a HK-MoCA score falling below the 2nd percentile of his/her peers adjusted for age and education
- cannot proficiently communicate due to language function impairment
- have severe skin lesions on acupressure areas
- had a surgery on the head or neck
- have a medical condition that is a contraindication for acupressure.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-08-24