NCT07775196 · NOT YET RECRUITING
Aging and Exercise Impacts on Glymphatic Function
This study looks at whether a single session of aerobic exercise changes how fluid moves through the brain, using MRI scans. Researchers are interested in the brain's waste-clearance system, called the glymphatic system. Healthy adults ages 25 to 75 take part. There is no placebo group. It is an early research study, not a test of any treatment.
You may qualify if
- age 25-75 years old
- cognitively unimpaired (CU)
- Mini-Mental State Examination (MMSE) score ≥27 at enrollment screening
- matched gender
- all racial/ethnic groups
You're excluded if
- pregnant women
- history of stroke or other major cerebrovascular disease;
- diagnosis of Alzheimer's disease (AD) or other types of dementia;
- diagnosis of major neurologic and psychiatric disorders (e.g., Parkingson's disease, major depression);
- history of prior head trauma, significant autoimmune disorders,
- sleep apnea;
- major systemic illness likely to affect the central nervous system, e.g., uncontrolled diabetes, severe cardiovascular disease, cancer, etc.;
- prior or current alcoholism or drug abuse;
- resistant hypertension (SBP ≥140 or DBP ≥ 90 mmHg despite 3 antihypertensive drugs at maximal doses);
- orthostatic hypotension defined as the third standing systolic blood pressure (SBP) \< 100mmHg; any contraindications to having a MRI, e.g., claustrophobia, pacemaker or other medical device of metal;
- any conditions judged by the investigators to be medically inappropriate, risky or likely to cause poor study compliance.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-10-05