NCT07753382 · NOT YET RECRUITING
Effects of Adaptive Difficulty Computerized Cognitive Training on Cognitive Function Improvement in Older Adults With Mild Cognitive Impairment
This trial is testing whether a computerized brain-training program that automatically adjusts its difficulty level can improve thinking and memory in older adults with mild cognitive impairment (MCI). It also compares whether continuing the training at a high frequency after the initial 12 weeks works better than stopping it. This is a Phase N/A behavioral study conducted in China — meaning it is evaluating a non-drug intervention rather than a medication.
You may qualify if
- Age >= 60 years;
- Planning to reside in the community for at least 12 months, with no intention to move into a nursing home;
- No clinical diagnosis of dementia;
- Meeting the diagnostic criteria for mild cognitive impairment (MCI) as defined in the Chinese Expert Consensus on the Diagnosis and Treatment of Alzheimer's Disease-Related Mild Cognitive Impairment (2021), The cut-off scores for the Beijing version of the Montreal Cognitive Assessment (MoCA) were adjusted for educational level: \<=13 for junior high school or below, \<=19 for high school, and \<=24 for college education or above. Mini-Mental State Examination (MMSE) score >= 24; Activities of Daily Living (ADL) score \<23.
- Able to use a mobile application (mini program) to perform cognitive training.
You're excluded if
- Individuals unable to complete the questionnaires due to hearing or visual impairments;
- Those with other organic diseases of the central nervous system, such as brain tumors, epilepsy, or Parkinson's disease;
- Those diagnosed with severe mental disorders, such as schizophrenia, depression, or anxiety disorders.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-08-07