NCT07458620 · Phase 1 · NOT YET RECRUITING
Prospective Single-Arm Safety Study of Cervical LVA in AD Patients
This trial tests whether a neck microsurgery is safe for people who already have Alzheimer's. Surgeons connect lymphatic vessels in the neck to nearby small veins, hoping to help the brain clear waste proteins. It is a Phase 1 trial, meaning an early check on safety in a small group, not proof that it works.
You may qualify if
- Diagnosis of Alzheimer's Disease: Participants must have a confirmed diagnosis of Alzheimer's Disease as evaluated by a neurologist and a psychiatrist at the hospital.
- Positive Amyloid-PET Scan: The result of a [18F] Florbetapir (Amyloid-PET) scan must be positive, indicating the presence of amyloid plaques in the brain.
- Willingness to Consent: Participants or their legal representatives must be willing to sign a written informed consent form.
- Participants must be adults aged 18 years or older
You're excluded if
- Lack of Informed Consent: Potential participants are excluded if they are unable to exercise autonomy and informed consent cannot be obtained from a legal representative or authorized person.
- Prior Surgical History: Individuals who have previously undergone neck lymphatic dissection, nasopharyngeal surgery, or intracranial surgery are excluded.
- Concurrent Medical Conditions: The trial excludes persons with thyroid disease or chronic heart failure.
- Specific Allergies: Candidates with a history of allergies to shellfish or iodine are excluded due to the use of Indocyanine Green (ICG) during the procedure.
- Unresolved Concerns: Anyone who has doubts about the trial and cannot receive satisfactory answers is excluded.
- Anesthesia Risks: Individuals deemed medically unfit for general anesthesia-for example, those with severe cardiopulmonary insufficiency or a history of specific anesthetic drug allergies-are ineligible.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-09