NCT07410052 · NOT YET RECRUITING
Microbiome-Targeted Enhancement of Neurocognition With Probiotics-Riboflavin Combination
This trial is testing whether a combination of a probiotic (Lactobacillus rhamnosus GG) and riboflavin (vitamin B2) delivered to the colon can improve memory and brain function in older adults with mild memory complaints. Participants take the supplements daily for 12 weeks. It is a Phase NA study, meaning it is a well-controlled pilot or feasibility trial rather than a late-stage efficacy study. Details on scale and funding are limited.
You may qualify if
- Age > 65 years
- MoCA scores 18-25 points
- BMI of 20.0 - 29.9 kg/m2 at screening
- Stable body weight (≤ 5% change) over the past 3-months
- Willing to avoid consuming gut microbiome-modulating dietary supplements within 4 weeks prior to the baseline visit
- Subjects will abstain from vitamin B2-rich food intake as per pre-defined list
- Maintain current level of physical activity
- Be willing and able to comply with trial protocol
You're excluded if
- Severe chronic disease and acute injuries
- History of dietary supplement use four weeks before enrolment
- Organic gastrointestinal (GI) disorders
- Bowel surgery or short bowel syndrome
- Gut-altering medications two months before enrolment
- Is currently using systemic steroids, proton pump inhibitors, H2 blocker, antacid
- History of drug and/or alcohol abuse at the time of enrolment
- Smoker or vaper
- Has made any major dietary changes in the past 3 months prior to baseline
- Has a currently active eating disorder
- Has food allergies or other issues with foods
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-13