NCT07271524 · NOT YET RECRUITING
Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury
This study tests whether gentle electrical stimulation applied through the scalp, aimed at the brain's memory and navigation region, improves spatial navigation in people with a past traumatic brain injury. Participants find hidden objects in a virtual reality arena while researchers record brain activity. It is not a phase-labeled trial, so it is an early research study, not proven or approved.
Eligibility criteria
Inclusion Criteria: * Age ≥ 18 years * Clinical diagnosis of TBI * No history of other severe neurological or psychiatric disorders Exclusion Criteria: * Unable to consent * Severe neuropsychiatric (e.g., major depression, severe dementia) or unstable systemic diseases (e.g., severe progressive and unstable cancer, life threatening infectious diseases) * Severe sensory or cognitive impairment or musculoskeletal dysfunctions prohibiting to understand instructions or to perform the experimental tasks * Inability to follow or non-compliance with the procedures of the study * Contraindications for NIBS or MRI: * Electronic or ferromagnetic medical implants/device, non-MRI compatible metal implant * History of seizures * Medication that significantly interacts with NIBS being benzodiazepines, tricyclic antidepressants and antipsychotics * Regular use of narcotic drugs * Pregnancy * Request of not being informed in case of incidental findings * Concomitant participation in another trial involving probing of neuronal plasticity
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-12-09