NCT07213648 · ACTIVE NOT RECRUITING
Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3)
This trial tests a phone app called MindTrails-Movement, which uses short mental exercises to shift how people interpret ambiguous situations, with the goal of lowering anxiety. It is for people with Huntington's or Parkinson's disease. Anxiety scores are compared against a waitlist group. The trial is early-stage, so it is checking preliminary results, not proven benefit.
You may qualify if
- Clinical diagnosis of Huntington's disease or Parkinson's disease (genetic diagnosis of HD also acceptable)
- With anxiety symptoms (NeuroQoL Anxiety ≥12)
You're excluded if
- Cognitive decline precluding ability to consent or complete the intervention (MoCA 5 min/telephone ≤11)
- Unable to read and understand English
- Does not have regular access to an internet-connected device, capable of downloading and installing the mobile application (i.e., tablet or iPhone running iOS 10 or later or an Android phone running Android 5.0 or later)
- Not located in the USA
- \<21 years old
- Active suicidality based on the answer "yes" to questions 4, 5, or 6b of the Columbia-Suicide Severity Rating Scale (Screen version)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-07-20