NCT06693466 · NOT YET RECRUITING
Huntington's Disease and Pain
This small pilot study in Huntington's disease is testing whether three standardized pain test sets can be carried out in people with the condition. The tests look at facial expressions, body movements and sounds in response to pain, and at how the body dampens or amplifies pain. No drug is given. The phase is unspecified. It is an early feasibility check, not a test of a treatment.
You may qualify if
- Genetically and clinically confirmed Adult-onset HD patients (≥ 21 years, CAG repeats ≥ 36; DCL of 4).
- Good general health apart from having HD. Note: Patients with chronic illness (e.g. hypertension) will be eligible if the illness is stable and well-controlled according to the investigator that will not impact the primary objectives of the study.
- Able to give written informed consent
You're excluded if
- Juvenile and Pediatric Huntington's Disease (age at onset \<21 years).
- Patients in the late stage of the disease (UDHRS-TFC score \<3).
- Have medical, psychiatric, or other conditions (other than HD) that, according to the investigator, may compromise the patient's ability to understand the patient information sheet, to give informed consent, to comply with all study requirements, or to perform study assessments.
- Have a history of (in the past year) or current (ab)use of any drug, alcohol or medication that, in the opinion of the investigator, may seriously interfere with the primary objectives of the study.
- The presence of a sensorimotor neuropathy or any another disturbance significantly disturbing the somatosensory systems, based on medical history and/or clinical examination, that can interfere with the pain test battery.
- Women who are pregnant or breastfeeding
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-11-18