NCT06628297 · NOT YET RECRUITING
Comparison of Differencens in VO2-max, Perfusion of the Heart and Brain and Cognitive Performance Between Patients with Type 2 Diabetes and Healthy Age Matched Controls.
This study compares people with type 2 diabetes to healthy people of the same age. Researchers use PET scans to measure blood flow in the heart and brain, along with fitness (VO2-max) and thinking tests. They want to know if small blood vessel problems link to weaker fitness and cognition. No phase is listed. It is an observational comparison, not a treatment test.
Eligibility criteria
Inclusion Criteria for the patients with type 2 diabetes: Diabetes type II diagnose with one of the following: * Duration over 5 years * Moderate microalbuminuria * Non-proliferative diabetic retinopathy * Speaks and understands Danish (required for reliable cognitive testing) * Able to provide informed and written consent Exclusion Criteria or the patients with type 2 diabetes: Moderate to high intensity training >1 times/week. * Previous AMI, atrial fibrillation, significant cardiac valve disease, HFrEF (LVEF \<45%), asthma. * Previous stroke or significant neurological disease including cognitive dysfunction. * Ongoing depression. * Hypothyroidism * Unable or unwilling to participate in training, e.g., due to injury, arthrosis or lung disease. Inclusion Criteria for the healthy age-matched controls: * Age > 60 years * No diagnosis of T2D according to WHO\'s criteria. * Speaks and understands Danish (required for reliable cognitive testing) * Able to provide informed and written consent Exclusion Criteria for the healthy age-matched controls: * Moderate to high intensity training >2 times/week. * Previous AMI, atrial fibrillation, significant cardiac valve disease, HFrEF (LVEF \<45%), asthma. * Previous stroke or significant neurological disease including cognitive dysfunction. * Ongoing depression. * Hypothyroidism * Unable or unwilling to participate in training, e.g., due to injury, arthrosis or lung disease.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-10-04