NCT06322121 · ACTIVE NOT RECRUITING
Vascular Aspects in Dementia: Part 2
This study uses MRI brain scans to track how well small blood vessels in the brain respond to a visual stimulus, and how that changes over time. It follows healthy adults and people with early memory problems or early Alzheimer's. No drug is given. It is an observational study, so it measures changes rather than testing a treatment.
Eligibility criteria
Inclusion Criteria:
* For this study three different routes for inclusion exists. Inclusion criteria for each group separately are shown below.
1. Participants who were included in our previous CASCADE study (P19.039).
* Capable of giving informed consent (see appendix)
2. Patients who attended a memory clinic within one year ago
* Diagnosed with (mixed) probable AD
* Diagnosed as MCI
* Diagnosed as SCI
* Age between 50-90 years
* Capable of giving informed consent (see appendix)
3. Control subjects
* Healthy adults without memory complaints
* Age between 50 -90 years
* Capable of giving informed consent
Exclusion Criteria:
* Contra-indication to MRI scanning:
* Claustrophobia
* Pacemakers and defibrillators
* Nerve stimulators
* Intracranial clips
* Intraorbital or intraocular metallic fragments
* Cochlear implants
* Ferromagnetic implants
* Hydrocephaluspump
* Intra-utrine device (not all types) Permanent make-up
* Tattoos above the shoulders (not all)
* Specific contraindications to fMRI
* Seizure within prior year.
* Noncorrectable visual impairment.
* MMSE \< 19 points (measured at moment of screening or at memory clinic with a maximum of 6 months in retrospect)
* Severe physical restrictions (completely wheelchair dependent)
* Age above 90The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-09-15