NCT06042413 · NOT YET RECRUITING
Prediction and Prevention of Postoperative Mortality and Morbidity
This study is building a tool to predict which older adults are at higher risk of death, heart or stroke events, and memory or thinking problems after heart or vascular surgery. It also tests a preparation program before surgery, including exercise, brain training, meditation, and social support. It is not a drug trial, and no phase applies.
Eligibility criteria
Part I Inclusion Criteria: * 65 years of age and older * Scheduled for major cardiac surgeries including coronary artery bypass and valvular repair and/or vascular surgeries including carotid endarterectomy, aortic aneurysm repair, and major vascular surgeries * Informed consent * English speaking patients Part II Inclusion Criteria: * Enrolled in Aim 1 / Part I Preoperative Intervention Trial * Scheduled for high-risk, cardiac or vascular surgery requiring intraoperative neurophysiological monitoring (IONM) Part I Exclusion Criteria: * Children (\<18 years) * Patients unable to provide consent * Participants undergoing same day procedures or operations (discharged same day) * Patients with severe preoperative medical diseases such as blindness or significant visual impairment, unresolved motor weakness, or any other perioperative events or complications that would have a bearing on the patient's ability to perform study tasks, neuropsychological tests, and proposed interventions Part II Exclusion Criteria: * Pregnant women * Patients do not provide consent. * Patients are unable to participate in cognitive and other behavioral assessment due to physical limitations * Patients refuse any blood transfusions during surgery
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-09-25