NCT05163626 · NOT YET RECRUITING
Combined Aerobic Exercise and Cognitive Training in Seniors at Increased Risk for Alzheimer's Disease
This trial tests whether a long-term program combining aerobic exercise and brain-training tasks affects thinking skills and blood levels of proteins tied to synapses, the connections between brain cells. It is a behavioral study with no drug involved. No phase applies, since that label is for drug trials. Results won't prove prevention of anything.
You may qualify if
- Mandarin-speaking subjects.
- Not clinically demented.
- Meeting the cutoff values of MMSE and CDR.
- With low levels of blood neuro-exosomal synaptic proteins (GAP43\<1983pg/ml, synaptotagmin 1\<431pg/ml, neurogranin\<1433pg/ml, SNAP25\<448pg/ml)
You're excluded if
- Had major neurologic diagnosis (e.g., Alzheimer's disease, Parkinson's disease, stroke, encephalitis, and epilepsy) or other condition that might impair cognition or confound assessments.
- Had a history of psychotic episodes or had major depression (Hamilton Depression Rating Scale score > 24 points).
- Had severe systemic diseases, such as tumors, cardiovascular or orthopedic disorders that can affect the ability to perform the proposed intervention tasks.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2023-07-24