NCT05163067 · NOT YET RECRUITING
Combined Aerobic Exercise and Cognitive Training in Seniors With Genetic Susceptibility for Alzheimer's Disease
This study tests whether a long-term program combining aerobic exercise and brain-training tasks can improve thinking skills, daily functioning, emotional well-being, and signs of brain adaptability in older adults. It is a behavioral study, not a drug trial, so there is no phase. Participants are people with certain genetic risk markers.
You may qualify if
- Mandarin-speaking subjects.
- Not clinically demented.
- Meeting the cutoff values of MMSE and CDR.
- With positive variation of rs3777215, rs234434, rs71352238, and rs4420638.
You're excluded if
- Had major neurologic diagnosis (e.g., Parkinson's disease, stroke, encephalitis, and epilepsy) or other condition that might impair cognition or confound assessments.
- Had a history of psychotic episodes or had major depression (Hamilton Depression Rating Scale score > 24 points).
- Had severe systemic diseases, such as tumors, cardiovascular or orthopedic disorder that can affect the ability to perform the proposed intervention tasks.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2023-07-21