NCT01887899 · WITHDRAWN
Influence of tDCS on Cortical Plasticity in Patients With Dementia of the Alzheimer Type
This study tests whether a gentle, painless electrical current applied to the scalp over the brain's movement area changes how flexible the brain's wiring is. It compares real stimulation with a fake version in people with mild to moderate Alzheimer's dementia. The outcome is a change in muscle-twitch signals. It has no phase because it is a device study, not a drug trial.
You may qualify if
- Right-handed according to the Oldfield Händigkeits inventory (lateralization index> 70) (1971)
- Cognitive impairment, which corresponds to a mild to moderate DAT
- No treatment with AChE inhibitors, or existing stable treatment with AChE inhibitors for over 3 months
- No motor impairments relevant to everyday life
- Age 50 to 80 years
- Existing Insurance certificate
- Existing informed consent
You're excluded if
- Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
- Epilepsy, epileptic seizure in medical history
- Cognitive deficit (MMSE \<20)
- Depressive episode (Beck Depression Inventory (BDI)> 12)
- intake of centrally active drugs \<3 months, particularly acetylcholinesterase inhibitors
- Pregnancy
- Pacemaker (contraindication for MRI)
- Other metal parts in the body (contraindication for MRI)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2021-05-14