NCT01800214 · ACTIVE NOT RECRUITING
The Sunnybrook Dementia Study
This is an observational study, not a treatment trial. Nobody is given a drug. Researchers follow people with memory problems or dementia, plus healthy older adults, once a year. They use brain MRI scans, genetic testing, and memory and daily-function tests to track how the brain changes over time. No phase applies.
Eligibility criteria
Patient Inclusion Criteria (General): * Age between 40 and 90 (inclusive) * Fluent in English * Completed 8 years of education or higher * Visual and auditory acuity adequate for neuropsychological testing * Mini-Mental State Exam (MMSE) score ≥ 16 Patient Exclusion Criteria (General): * Possible secondary causes of dementia, concomitant or history of neurological or psychiatric illness (other than stroke or Parkinsonism) * History of alcohol or substance abuse or dependence within the past 2 years Normal Control Inclusion Criteria: * Age between 40-90 * Fluent in English * Completed 8 years of education or higher * No significant memory complaints Normal Control Exclusion Criteria: * Being treated or history of being treated for psychiatric or neurological illness * History of alcohol or substance abuse or dependence within the past 2 years * Current use of psychoactive medications (e.g. antidepressant, neuroleptics, chronic anxiolytics or sedative hypnotics, etc.) * Medical contraindications to MRI
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-25