NCT01638949 · COMPLETED
Multi-modal Neuroimaging in Alzheimer's Disease IMAP+
This is an observational study, not a drug test. Researchers use memory tests, blood markers, MRI and PET brain scans to follow people over time, from healthy young adults to those with Alzheimer's. The goal is to see how different early-warning signs relate to each other and change. Nobody receives a treatment, so there is no phase.
Eligibility criteria
Inclusion Criteria : * Education level > 7 years * Native language: French * Medical, neurological, neuropsychological and neuroradiological depth in accordance with the criteria for inclusion and exclusion-specific population, that is to say: * Healthy young volunteers: between 18 and 40 years old; normal performances compared to the age and the educational level for all tests of the diagnostic battery (± 1.65 SD). * Healthy Middle-aged volunteers: between 40 and 60 years old; without memory complaints, normal performances compared to the age and the educational level for all tests of the diagnostic battery (± 1.65 SD). * Healthy Elderly volunteers: over 60 years old, living at home, without memory complaints, normal performances compared to the age and the educational level for all tests of the diagnostic battery (± 1.65 SD). * SCI patients: over 60 years old ; memory complaints; memory complaint ; normal performances compared to the age and the educational level for all tests of the diagnostic battery (± 1.65 SD). * MCI patients: presenting the current criteria for amnestic MCI including: i) memory complaint, ii) deficits of the episodic memory (lower performance of at least 1.65 SD from the norm for age and cultural level for one or more scores of episodic memory and iii) normal performances compared to the age and the educational level of all other cognitive functions as memory, including tests to assess cognitive abilities. * Alzheimer's patients: presenting the standard criteria of NINCDS-ADRDA probable Alzheimer's disease, including abnormal global cognitive function and deficits in at least two cognitive domains identified by the diagnostic battery and a mild to moderate Alzheimer's disease (MMSE ≥ 15). Exclusion Criteria : * The sudden onset of cognitive impairments (as opposed to their slow and gradual installation in Alzheimer's disease) * A chronic neurological, psychiatric, endocrine, hepatic or infectious complaint * A history of major disease (an uncontrolled diabetes, a lung, heart, metabolic, hematologic, endocrine disease or a severe cancer) * A medication that may interfere with memory or metabolic measures * A alcohol or drugs abuse * The cons-indications to MRI (claustrophobia, metallic object in the body) * A predominantly left-hand (score below 50% in Edinburgh Inventory) * Protected adults, and persons not affiliated with a social security system will not participate in this study * The inclusion of a participant in another biomedical research protocol
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-04-02