NCT01231295 · COMPLETED
Isotopic Imaging for Prodromal Alzheimer's Disease
This study compares two brain scans, FDG PET (which shows how actively the brain uses sugar) and SPECT (which shows blood flow), in people with early memory problems. Researchers want to see which scan better picks up early Alzheimer's changes. No drug or treatment is given. The phase is not specified, and this is a diagnostic imaging study.
Eligibility criteria
Inclusion Criteria for the group with memory problems: * patient consulting for memory problems * caucasian * memory complaint is validated by a clinical evaluation * cognitive performance is sufficiently well preserved so that a diagnostic of dementia cannot be made (according to the DSM-IV-R and NINCDS-ADRDA criteria) at the time of inclusion * the patient speaks French * presence of an informant * accepts to sign consent Inclusion Criteria for the group without memory problems (reference population): * at least four years of formal education * patient consulting for memory problems * memory problem reported by the patient is not validated by the consultation, nor by the battery of tests specified during screening * presence of an informant * Clinical Dementia Rating (CDR) = 0 * accepts to sign consent Exclusion Criteria: * Instrumental Activities of Daily Living (IADL): at least two items > 1 * Anticholinesterasic treatments and/or memantin before study inclusion * major depressive syndrome, according to the Global Depressive Scale * Known neurodegenerative disease or general disease or major physical problems that could interfere with cognitive functioning and testing * Pathology that might lead to death in the short term (evolving cancer, non stable cardiopathy, hepatic, renal or respiratory insufficiency) * contra-indications for MRI, PET or SPECT scans * not affiliated with a social security regimen
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2017-02-01