All of this “advice” came from a doctor, a podcast or a study. Half of it contradicts the other half. None of it was written for your genotype.
Cut cholesterol.Go Keto.Avoid saturated fat at all costs.Eat more healthy fats.Take statins.Statins are dangerous.Mediterranean diet is best.
Cut cholesterol.Go Keto.Avoid saturated fat at all costs.Eat more healthy fats.Take statins.Statins are dangerous.Mediterranean diet is best.
Cut cholesterol.Go Keto.Avoid saturated fat at all costs.Eat more healthy fats.Take statins.Statins are dangerous.Mediterranean diet is best.
Cut cholesterol.Go Keto.Avoid saturated fat at all costs.Eat more healthy fats.Take statins.Statins are dangerous.Mediterranean diet is best.
Carnivore is the only way.Intermittent fasting will save your brain.Fasting is dangerous for APOE4.This supplement is a game-changer.Supplements don't work, waste of money.Drink red wine for brain health.Alcohol destroys neurons, quit entirely.
Carnivore is the only way.Intermittent fasting will save your brain.Fasting is dangerous for APOE4.This supplement is a game-changer.Supplements don't work, waste of money.Drink red wine for brain health.Alcohol destroys neurons, quit entirely.
Carnivore is the only way.Intermittent fasting will save your brain.Fasting is dangerous for APOE4.This supplement is a game-changer.Supplements don't work, waste of money.Drink red wine for brain health.Alcohol destroys neurons, quit entirely.
Carnivore is the only way.Intermittent fasting will save your brain.Fasting is dangerous for APOE4.This supplement is a game-changer.Supplements don't work, waste of money.Drink red wine for brain health.Alcohol destroys neurons, quit entirely.
Blueberries reverse cognitive decline.Antioxidants are overhyped.You need MCT oil every morning.MCTs are pointless unless you're in ketosis.Avoid eggs: cholesterol bomb.Eggs are the ultimate brain food.
Blueberries reverse cognitive decline.Antioxidants are overhyped.You need MCT oil every morning.MCTs are pointless unless you're in ketosis.Avoid eggs: cholesterol bomb.Eggs are the ultimate brain food.
Blueberries reverse cognitive decline.Antioxidants are overhyped.You need MCT oil every morning.MCTs are pointless unless you're in ketosis.Avoid eggs: cholesterol bomb.Eggs are the ultimate brain food.
Blueberries reverse cognitive decline.Antioxidants are overhyped.You need MCT oil every morning.MCTs are pointless unless you're in ketosis.Avoid eggs: cholesterol bomb.Eggs are the ultimate brain food.
Coffee protects your brain.Coffee spikes your cortisol, avoid.Dairy is inflammatory.Dairy is a superfood, try kefir.Don't stress, relaxation is key.Challenge your brain every day.
Coffee protects your brain.Coffee spikes your cortisol, avoid.Dairy is inflammatory.Dairy is a superfood, try kefir.Don't stress, relaxation is key.Challenge your brain every day.
Coffee protects your brain.Coffee spikes your cortisol, avoid.Dairy is inflammatory.Dairy is a superfood, try kefir.Don't stress, relaxation is key.Challenge your brain every day.
Coffee protects your brain.Coffee spikes your cortisol, avoid.Dairy is inflammatory.Dairy is a superfood, try kefir.Don't stress, relaxation is key.Challenge your brain every day.
The signal
One protocol. Tuned to your genotype. Proved by your bloodwork.
708+carriers running it27markers watched89%see a marker move
The math of APOE4
Your risk isn't fixed. It's a number you can move.
An APOE 4/4 genotype can push lifetime Alzheimer's risk toward 60 percent. In the FINGER trial, APOE4 carriers got 2.6× more cognitive benefit from multidomain intervention than non-carriers. The gene loads the dice. It doesn't throw them.
Genin 2011Ngandu 2015 (FINGER)Fortea 2024
Lifetime risk by age 85Scale 0–100%
~60%
APOE 4/4 untreated
Measured · Genin 2011
~22%
APOE 4/4 optimized
Modeled · FINGER-style protocol
About 63% lower risk in the optimized scenario
How it works
Your personal protocol. Tested against your own results.
Start with what matters for your genes. Track what you do, review your progress, and use your own numbers to decide what to keep or change.
01
Your protocol
What to try first, ranked for your genes and your bloodwork.
800+ APOE4 papers
1,300 live clinical trials
What worked for carriers like you
Personalized to your health profile
02
Daily check-in
90 seconds to record what you do and how you feel.
1Supplements
2Movement
3Sleep
4Nutrition
Your monthly review
03
Your progress
Bring your 90-day blood test. See what improved and what needs to change.
89%of members improve at least one APOE4 biomarker within 3 months.
27 biomarkers
Result
Phoenix AIYour results guide the next step in your personal protocol.
Learn from each other
708+ carriers are testing what works for their genes. Learn from their results, then check it with your own.
708+ APOE4 carriers
You don't run it alone
Your carrier circle. 2–4 people who get it. Working on the same goals as you.
New carrier circles form on the 1st of every month. Members in a circle stay consistent 3.2x longer than members going it alone.
Pod matching opens monthly
Your carrier circle
Marker discipline. Record every start, stop, and dose.
Sample circle
YouYou
Deb
John
Donna
Deb7:14 a.m.
Held the glucose protocol all month and kept every pound of muscle. It wasn't one supplement. It was staying consistent because you all check in on me.
John9:02 a.m.
That's the push I needed. My p-tau came back 0.09, half the borderline threshold.
Phoenix AI · Pattern detection
Five members. Five different stacks. One thing in common.
Each lowered LDL-C on a stack that looks nothing like the others. Phoenix AI reads across all five and surfaces the one intervention they share.
1
Member 1
APOE3/4 · 62 · F
142→98mg/dL−31%
Vitamin D3
Creatine
Magnesium threonate
Ezetimibe
Lithium orotate
2
Member 2
APOE4/4 · 58 · M
163→121mg/dL−26%
Glycine
Ezetimibe
Vitamin K2
Curcumin
Taurine
3
Member 3
APOE3/4 · 47 · F
128→89mg/dL−30%
Lutein
Magnesium glycinate
Ezetimibe
NAC
Vitamin C
4
Member 4
APOE4/4 · 56 · F
171→112mg/dL−35%
Ezetimibe
Vitamin D3
Vitamin B12
Folate
Melatonin
5
Member 5
APOE4/4 · 43 · M
151→109mg/dL−28%
Creatine
Lithium orotate
Zinc
Ezetimibe
Citicoline
Pattern found
Ezetimibe
5 / 5
members share it
−30%
median LDL-C change
Illustrative members · intervention names from the Phoenix library
Phoenix AI · Members like you
You want to lower fasting insulin. Your twins already did.
Phoenix matches you to members who share your profile, then ranks what actually moved their number.
You
Female55APOE4/4HbA1c 5.7%Insulin 14 µIU/mL
12 members share your profile
9 lowered fasting insulin
What worked for them
ranked by twins who improved
Berberine
−31%9 of 12 twins
Zone-2 cardio · 3×/wk
−27%7 of 12 twins
Time-restricted eating
−24%6 of 12 twins
Alpha-lipoic acid
−18%5 of 12 twins
Magnesium glycinate
−9%4 of 12 twins
Illustrative · change = median fasting-insulin change across twins who logged the intervention and retested
What you'll track
The lab said normal. For a 4/4 carrier, it isn't.
27 markers, each read against its medical context rather than one guessed universal range. Here are four of them.
Biomarker
Lab “normal”
Phoenix target
Why the gap matters
ApoB
mg/dL
Lab normal< 90
Phoenix targetBy risk tier
Phoenix uses the reviewed cardiovascular risk tier instead of assigning a target from APOE4 alone.
pTau-217
pg/mL
Lab normalNot run
Phoenix targetBy assay
Nobody orders it. It detects Alzheimer's pathology up to 20 years before symptoms.
Omega-3 Index
%
Lab normal> 4
Phoenix target> 8
APOE4 brains are starved for DHA. The standard floor is half what you need.
hs-CRP
mg/L
Lab normal< 3.0
Phoenix targetRisk context
APOE4 brains run hot. Chronic inflammation multiplies amyloid deposition rather than adding to it.
+ 23 more in the dashboard · every range backed by a peer-reviewed citation
Three of dozens. Real names, real genotypes, real numbers they moved.
Dr. John Yoder, 68
Retired Physician · Missouri
3/4
0.09
p-tau · half of borderline
● Verified by labs
“I would have never heard of P-tau testing without this group. Even if none of this prevents Alzheimer’s, I’m living these years healthy and energetic.”
Phoenix is a one-person, founder-led startup. I spent years working on Alzheimer’s and it turns out I carry two copies of the highest risk gene. When my result came back, my doctor told me what yours probably did: “come back when you have symptoms”. This is unacceptable. I read 800 papers, consulted 40 researchers and experts, and built the protocol and community I needed.
Phoenix AI
708+ APOE4 carriers